Information of ICE
| ICEberg ID | 3 |
|---|---|
| ICE Name | CTnDOT |
| ICEO ID | ICEO_0000701 |
| Organism | Bacteroides thetaiotaomicron |
| Size | ~65 kb |
| GC Content (%) | - |
| Insertion site | TTTGCNNNNN |
| Function | R Tetracycline and erythromycin resistance |
| Species that ICE can be transferred to | Bacteroides thetaiotaomicron; Bacteroides spp.; Escherichia coli |
| Nucleotide Sequence | AJ431573; AF289050; AJ319661; AJ311171 (partial ICE sequence) |
| Coordinates | 1..16256 |
| Putative oriT region | - |
| Putative relaxase | coordinates: 7955..8866; Family: MOBP |
Function tags R Antibiotic resistance V Virulence factor M Metal resistance D Defense system G Degradation S Symbiosis
The graph information of CTnDOT components from AF289050
Complete gene list of CTnDOT from AF289050
| # | Gene | Coordinates [+/-], size (bp) | Product (GenBank annotation) | Reannotation | Rea |
|---|
The graph information of CTnDOT components from AF289050
Complete gene list of CTnDOT from AF289050
| # | Gene | Coordinates [+/-], size (bp) | Product (GenBank annotation) | Reannotation | Rea |
|---|
The graph information of CTnDOT components from AF289050
Complete gene list of CTnDOT from AF289050
| # | Gene | Coordinates [+/-], size (bp) | Product (GenBank annotation) | Reannotation | Rea |
|---|
The graph information of CTnDOT components from AF289050
Complete gene list of CTnDOT from AF289050
| # | Gene | Coordinates [+/-], size (bp) | Product (GenBank annotation) | Reannotation | Rea |
|---|
The Interaction Network among ICE/IME/CIME
Detailed Informatioin of the Interaction Network
| # | ICE | Inter_Ele [Type] | Methods | Donors | Recipients | Exper_Ref |
|---|---|---|---|---|---|---|
| 1 | CTnDOT | ermF region [IME] |  in trans | Bacteroides thetaiotaomicron | Bacteroides thetaiotaomicron | 11472924 |
| 2 | CTnDOT | NBU1 [IME] | in trans | Bacteroides uniformis | Bacteroides thetaiotaomicron 5482 | 8407835 |
| 3 | CTnDOT | NBU2 [IME] | in trans | Bacteroides thetaiotaomicron; Bacteroides uniformis | Bacteroides thetaiotaomicron 5482 | 8407835 |
| 4 | CTnDOT | Tn4399 [IME] | in trans | Bacteroides | Bacteroides | 8397185 |
| (1) Bedzyk LA, Shoemaker NB, Young KE, Salyers AA. (1992) Insertion and excision of Bacteroides conjugative chromosomal elements. J Bacteriol. 1992 Jan;174(1):166-72. [PubMed:1309516] |
| (2) Bedzyk LA, Shoemaker NB, Young KE, Salyers AA. (1992) Insertion and excision of Bacteroides conjugative chromosomal elements. J Bacteriol. 1992 Jan;174(1):166-72. [PubMed:1309516] |
| (3) Valentine PJ, Shoemaker NB, Salyers AA. (1988) Mobilization of Bacteroides plasmids by Bacteroides conjugal elements. J Bacteriol. 1988 Mar;170(3):1319-24. [PubMed:3343220] |
| (4) Li LY, Shoemaker NB, Salyers AA. (1995) Location and characteristics of the transfer region of a Bacteroides conjugative transposon and regulation of transfer genes. J Bacteriol. 1995 Sep;177(17):4992-9. [PubMed:7665476] |
| (5) Cheng Q, Paszkiet BJ, Shoemaker NB, Gardner JF, Salyers AA. (2000) Integration and excision of a Bacteroides conjugative transposon, CTnDOT. J Bacteriol. 2000 Jul;182(14):4035-43. [PubMed:10869083] |
| (6) Whittle G, Hund BD, Shoemaker NB, Salyers AA. (2001) Characterization of the 13-kilobase ermF region of the Bacteroides conjugative transposon CTnDOT. Appl Environ Microbiol. 2001 Aug;67(8):3488-95. [PubMed:11472924] |
| (7) Cheng Q, Sutanto Y, Shoemaker NB, Gardner JF, Salyers AA. (2001) Identification of genes required for excision of CTnDOT, a Bacteroides conjugative transposon. Mol Microbiol. 2001 Aug;41(3):625-32. [PubMed:11532130] |
| (8) Whittle G, Shoemaker NB, Salyers AA. (2002) Characterization of genes involved in modulation of conjugal transfer of the Bacteroides conjugative transposon CTnDOT. J Bacteriol. 2002 Jul;184(14):3839-47. [PubMed:12081954] |
| (9) Cheng Q, Wesslund N, Shoemaker NB, Salyers AA, Gardner JF. (2002) Development of an in vitro integration assay for the Bacteroides conjugative transposon CTnDOT. J Bacteriol. 2002 Sep;184(17):4829-37. [PubMed:12169608] |
| (10) Sutanto Y, Shoemaker NB, Gardner JF, Salyers AA. (2002) Characterization of Exc, a novel protein required for the excision of Bacteroides conjugative transposon. Mol Microbiol. 2002 Dec;46(5):1239-46. [PubMed:12453211] |
| (11) Whittle G, Shoemaker NB, Salyers AA. (2002) The role of Bacteroides conjugative transposons in the dissemination of antibiotic resistance genes. Cell Mol Life Sci. 2002 Dec;59(12):2044-54. [PubMed:12568330] |
| (12) Wang Y, Shoemaker NB, Salyers AA. (2004) Regulation of a Bacteroides operon that controls excision and transfer of the conjugative transposon CTnDOT. J Bacteriol. 2004 May;186(9):2548-57. [PubMed:15090494] |
| (13) Sutanto Y, DiChiara JM, Shoemaker NB, Gardner JF, Salyers AA. (2004) Factors required in vitro for excision of the Bacteroides conjugative transposon, CTnDOT. Plasmid. 2004 Sep;52(2):119-30. [PubMed:15336489] |
| (14) Wang Y, Rotman ER, Shoemaker NB, Salyers AA. (2005) Translational control of tetracycline resistance and conjugation in the Bacteroides conjugative transposon CTnDOT. J Bacteriol. 2005 Apr;187(8):2673-80. [PubMed:15805513] |
| (15) DiChiara JM, Salyers AA, Gardner JF. (2005) In vitro analysis of sequence requirements for the excision reaction of the Bacteroides conjugative transposon, CTnDOT. Mol Microbiol. 2005 May;56(4):1035-48. [PubMed:15853888] |
| (16) Moon K, Shoemaker NB, Gardner JF, Salyers AA. (2005) Regulation of excision genes of the Bacteroides conjugative transposon CTnDOT. J Bacteriol. 2005 Aug;187(16):5732-41. [PubMed:16077120] |
| (17) Malanowska K, Salyers AA, Gardner JF. (2006) Characterization of a conjugative transposon integrase, IntDOT. Mol Microbiol. 2006 Jun;60(5):1228-40. [PubMed:16689798] |
| (18) Dichiara JM, Mattis AN, Gardner JF. (2007) IntDOT interactions with core- and arm-type sites of the conjugative transposon CTnDOT. J Bacteriol. 2007 Apr;189(7):2692-701. [PubMed:17277054] |
| (19) Moon K, Sonnenburg J, Salyers AA. (2007) Unexpected effect of a Bacteroides conjugative transposon, CTnDOT, on chromosomal gene expression in its bacterial host. Mol Microbiol. 2007 Jun;64(6):1562-71. [PubMed:17555438] |
| (20) Malanowska K, Yoneji S, Salyers AA, Gardner JF. (2007) CTnDOT integrase performs ordered homology-dependent and homology-independent strand exchanges. Nucleic Acids Res. 2007;35(17):5861-73. [PubMed:17720706] |
| (21) Jeters RT, Wang GR, Moon K, Shoemaker NB, Salyers AA. (2009) Tetracycline-associated transcriptional regulation of transfer genes of the Bacteroides conjugative transposon CTnDOT. J Bacteriol. 2009 Oct;191(20):6374-82. [PubMed:19700528] |
| (22) Laprise J, Yoneji S, Gardner JF. (2010) Homology-dependent interactions determine the order of strand exchange by IntDOT recombinase. Nucleic Acids Res. 2010 Jan;38(3):958-69. [PubMed:19952068] |
| (23) Wood MM, Dichiara JM, Yoneji S, Gardner JF. (2010) CTnDOT integrase interactions with attachment site DNA and control of directionality of the recombination reaction. J Bacteriol. 2010 Aug;192(15):3934-43. [PubMed:20511494] |
| (24) Park J, Salyers AA. (2011) Characterization of the Bacteroides CTnDOT regulatory protein RteC. J Bacteriol. 2011 Jan;193(1):91-7. [PubMed:21037014] |